@article {99, title = {Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy.}, journal = {Clin Ophthalmol}, volume = {7}, year = {2013}, month = {2013}, pages = {1339-45}, abstract = {

PURPOSE: To describe immunohistopathological findings in autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV).

METHODS: An enucleated eye specimen from a patient with Stage V ADNIV was examined using standard histopathological methods and lymphocyte markers.

RESULTS: A c.731T\>C CAPN5 mutation resulted in a p.Leu244Pro substitution in calpain-5. The eye showed exudative retinal detachment and neovascularization, intraocular fibrosis, and features of phthisis bulbi. Chronic inflammatory CD3-positive cell infiltrates were identified throughout the uvea, vitreous and retina, consistent with chronic uveitis.

CONCLUSION: Mutations in CAPN5 trigger autoimmune uveitis characterized by inflammatory T-cells and severe neovascularization.

}, author = {Mahajan, Vinit B and Lin, Jonathan H} }